The supernatant was collected, and protein concentrations of phosphorylated (p)eNOSser1177, a primary activation site of eNOS,44 and peNOSthr495, a key site of eNOS inactivation,44 were determined by capillary electrophoresis immunoassay (Wes; ProteinSimple) using rabbit antibodies (Thermo Fisher). Critics have argued that there is no strong evidence to prove that masks slow the spread of Covid, and that in any case children werent wearing the right kinds of masks or werent wearing them properly. Overall, these results are promising and suggest highresistance IMST may lower ambulatory measures of SBP. *P<0.05 vs baseline. 1. Updates and new developments, http://ezproxy.utica.edu/login?url=https://dsm.psychiatryonline.org/. A companion database to Business Source Premier, Regional Business News provides comprehensive full text coverage for regional business publications. Immunocompromised individuals with known or suspected immunodeficiency, as determined by history and/or laboratory/physical examination. GPO (OCLC) offers several features not found in GPO Access: GreenFILE is a research database focusing on the relationship between human beings and the environment, with well-researched but accessible information on topics ranging from global warming to recycling to alternate fuel sources and beyond. Microsoft pleaded for its deal on the day of the Phase 2 decision last month, but now the gloves are well and truly off. S7). Philosopher's Index is considered the most thorough index of journal literature on the subject and features author-written abstracts covering scholarly research published in journals and books, including contributions to anthologies and book reviews. Investigator site staff or Pfizer employees directly involved in the conduct of the study, site staff otherwise supervised by the investigator, and their respective family members. more. UC Library does not maintain a subscription to access premium content. Schauer PR, Bhatt DL, Kirwan JP, et al. 2020 Dec 17;383(25):2439-2450. doi: 10.1056/NEJMoa2027906. SBP decreased from 1352mmHg at baseline to 1263mmHg after 6weeks of IMST (P<0.01) but was unchanged with sham training (baseline: 1342mmHg, endintervention: 1313mmHg; P=0.07). BioOne is an online aggregation of full text, high impact journals in the biological, ecological and environmental sciences. Britannica Online incorporates all articles from the print set with interactive, online features to offer a dynamic online resource: Search education literature and resources using the ERIC EbscoHost interface. Records represent the individual paper and note the event at which the paper was presented. Email: American Heart Association, Inc. All rights reserved. more. Male or female participants between the ages of 18 and 55 years, inclusive, 65 and 85 years, inclusive, or 12 years, inclusive, at randomization (dependent upon study phase). We found that 6weeks of highresistance IMST lowered casual SBP and DBP. In the semaglutide group, weight loss was observed from the first postrandomization assessment (week 4) onward, reaching a nadir at week 60 (Figure 1A and 1B). Contact Us. To search multiple databases at once, select each from the Choose Database screen. Participants who, in the judgment of the investigator, are at risk for acquiring COVID-19. This is a system organ class. Valuable tools for building a rewarding career in health care. Resource is free to all users. Most gastrointestinal events were mild-to-moderate in severity, were transient, and resolved without permanent discontinuation of the regimen (Fig. Magkos F, Fraterrigo G, Yoshino J, et al. This work was supported by National Institutes of Health awards R21AG061677, T32DK007135, UL1TR002535, P30CA046934 and American Heart Association Award 18POST33990034. JAMA 2013;310:2416-2425. There was no influence of sex on 24hour DBP (data not shown). The assessment of boostability will be further expanded in a subset of Phase 3 participants at selected sites in the US who will receive a third dose of BNT162b2 at 30 g or a third and potentially a fourth dose of prototype BNT162b2VOC at 30 g (BNT162b2s01, based upon the South African variant and hereafter referred to as BNT162b2SA). You can contact agencies. 2021;10:e020980. IMST decreased Creactive protein (P=0.05) and altered select circulating metabolites (targeted plasma metabolomics) associated with cardiovascular function. *Adverse events are shown for the safety analysis population (all randomly assigned participants exposed to at least one dose of trial drug or placebo); since all participants received at least one dose of drug or placebo, the safety population is the same as the full-analysis population. Partial least squaresdiscriminant analysis and heat maps with hierarchical clustering were prepared using MetaboAnalyst (Wishart Research Group, University of Alberta) version 4.0 following data normalization to median with autoscaling. Search authoritative medical information using the FirstSearch MEDLINE interface. Dr. Shira Doron, an infectious-disease physician at Tufts Medical Center in Boston who has criticized mask mandates in schools in the past, said that the new study was just one publication and that the medical literature on mask mandates in schools was mixed. Participants Table 1. Blood markers of systemic oxidative stress, antioxidant defenses, inflammation, and sympathoadrenal activity were measured by the Colorado Clinical and Translational Sciences Institute Clinical Translational Research Center Core Laboratory at baseline and endintervention. more. By continuing to browse this site you are agreeing to our use of cookies. You select a topic and define a personalized journal subset. A great resource for beginning your research. Free database of randomized trials, systematic reviews and practice guidelines for evidence-based physiotherapy or physical therapy. Betweengroup differences in individual plasma metabolites were assessed with unpaired t tests. This study shows that if people are wearing masks as a group, that it reduces transmission for everyone in the population, and it reduces school absences and teacher absences, Dr. Raifman said. Training session data were downloaded at the end of each week during supervised training sessions to determine adherence. Long-term persistence of hormonal adaptations to weight loss. Older individuals have a greater risk for cardiovascular diseases, partly because of increases in blood pressure and endothelial dysfunction. ROS, such as superoxide, readily react with NO, consequently reducing NO bioavailability. The study consists of 2 parts: Phase 1: to identify preferred vaccine candidate(s) and dose level(s); Phase 2/3: an expanded cohort and efficacy part. BioOne journals are published by scholarly societies, museums and other organizations, many of which are members of the American Institute for Biological Sciences. Content includes Civil War era newspapers and memoirs, African American newspapers, the history of women's suffrage, regimental histories, county histories, and more. 24. Compilation of 10 databases from OCLC, searchable together or separately. Digital access to the most comprehensive collection of American periodicals; documenting the life of America's people from the Colonial Era through the Civil War and Reconstruction, Business and financial information, trade and industry news, including local and regional business publications, This database is the online equivalent of print journal Abstracts in Anthropology. The plasma metabolome of each group was assessed with partial least squaresdiscriminant analysis, and heat maps with hierarchical clustering were prepared using MetabolAnalyst version 4.0 following data normalization to median with autoscaling. Read our, ClinicalTrials.gov Identifier: NCT04368728, Interventional There was a significant interaction effect for casual SBP for those who completed followup testing (P=0.01). Children with language-learning difficulties are having trouble understanding their teachers and their peers, Dr. Doron said. Current UC students, faculty and staff are encouraged to use GreenFILE through UC Library as more full text options may be available. Two important things should be noted here, however. more. New York Times Digital Microfilm starts in 2008. Potential participants were excluded if they had fasting plasma glucose 126mg/dL, total cholesterol 240mg/dL, uncontrolled thyroid disease, severe obesity (body mass index >40kg/m2), were not weight stable (>3kg change in body mass) for at least 3months before enrolling in the study, or had alcohol dependence determined through a medical history and physical exam performed by the University of Colorado Boulder Clinical Translational Research Center study physician. You have reached the maximum number of saved studies (100). more. Bettge K, Kahle M, Abd El Aziz MS, Meier JJ, Nauck MA. Healthy lifestyle interventions, such as aerobic exercise, are firstline strategies to lower BP and improve arterial function.6, 14 However, there are many deterrents to achieving healthy lifestyle guidelines, including time availability, cost, transportation, and mobility issues among others.18, 19, 20, 21, 22, 23 Here, we found that 30minutes per week of IMST performed with a handheld device promotes excellent rates of adherence, because subjects in the IMST group completed 95% of prescribed training sessions at the appropriate intensity. Both diet and activity were recorded daily in a diary or by use of a smartphone application or other tools and were reviewed during counseling sessions. With content designed specifically colleges and universities, this database is an excellent resource for background information on projects in history, arts, society, humanities, geography, science and technology. Access restricted to current Utica College students, faculty and staff. Baseline scores on the Impact of Weight on Quality of LifeLite Clinical Trials Version (IWQOL-Lite-CT; scores range from 0 to 100, with higher scores indicating better patient functioning) are reported for 1296 participants in the semaglutide group and 649 participants in the placebo group. All measurements were performed at the University of Colorado Boulder Clinical Translational Research Center or Integrative Physiology of Aging Laboratory. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. Efficacy end points were analyzed in the full analysis population (all randomly assigned participants according to the intention-to-treat principle); safety end points were analyzed in the safety analysis population (all randomly assigned participants exposed to at least one dose of semaglutide or placebo). Stay connected to what's important in medical research and clinical practice, Subscribe to the most trusted and influential source ofmedical knowledge, This article is available to subscribers. It has been reported that highresistance IMST reduces sympathetic activity in patients with obstructive sleep apnea, either measured directly with microneurography34 or using plasma norepinephrine concentrations.33 Our results do not show an obvious role for reductions in sympathetic activity contributing to improvements in cardiovascular function in our otherwise healthy midlife/older adults with abovenormal SBP. ), QUICK TAKE VIDEO SUMMARYOnce-Weekly Tirzepatide for Obesity01:48, Are you a member of an institution such as a university or hospital? Bylines: Newsweek, The Washington Times, MSN.com, The Washington Examiner, The Daily Caller, The Federalist, the Epoch Times. Nausea and diarrhea were the most common adverse events with semaglutide; they were typically transient and mild-to-moderate in severity and subsided with time. Data are meanSEM. The mean change in body weight from baseline to week 68 was 14.9% in the semaglutide group as compared with 2.4% with placebo, for an estimated treatment difference of 12.4 percentage points (95% confidence interval [CI], 13.4 to 11.5; P<0.001). Continuous end-point analyses were conducted with the use of the analysis-of-covariance method, with randomized treatment as a factor and baseline end-point value as a covariate and a multiple imputation approach for missing data.15 Analyses of categorical end points were conducted with the use of logistic regression, with the same factor and covariate. In the present study, IMST also was shown to be safe, with only 2 minor interventionrelated adverse events reported, which involved neck muscle soreness and transient lightheadedness. There were no baseline differences between groups in any measure of arterial stiffness, including CFPWV, carotid artery compliance, and beta stiffness index, or for carotid IMT (all P>0.05), and none of these outcomes changed following 6weeks of IMST or sham training (all P>0.05). No full text. This database covers the field of health management and administration. Williamson DA, Bray GA, Ryan DH. The researchers had hoped that masks would cut the infection rate by half among wearers. Millions of full-text articles, many with images. A further subset of Phase 3 participants will receive a third, lower, dose of BNT162b2 at 5 or 10 g. This article is commented on by the following: Epidemiology of cardiovascular disease in the United States: implications for the perfusion profession. Blood samples were drawn either via venipuncture (screening, followup testing) or from an intravenous catheter (baseline, endintervention) placed in an antecubital vein. Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity. Among the metabolites with the highest loading, we identified 3 potential markers of cardiovascularacting effects, which were observed to increase with IMST but not sham training: Lornithine, an amino acid and precursor for the NO substrate, Larginine57 (IMST: 1.330.09fold change, sham: 1.030.06fold change; P=0.01); indole, a microbial metabolite reported to decrease BP through central nervous system mechanisms58 (IMST: 1.310.17fold change, sham: 0.890.08fold change; P=0.03); and hexanoic acid, a shortchain fatty acid that may mediate antiinflammatory responses59 (IMST: 1.360.16fold change, sham: 0.960.09fold change; P=0.04). Unauthorized pic.twitter.com/yPdsSSQAbr. From the Section of Endocrinology and Metabolism, Department of Medicine, and the Section of Pediatric Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT (A.M.J. S9). Dr. Tracy Beth Hoeg, an epidemiologist and fierce critic of school masking, noted that the new study was observational and not a randomized, controlled clinical trial. This collection encompasses a wide range of topics from leading psychology and psychosomatic publications. Clase indexes documents published in Latin American journals specializing in the social sciences and humanities. Healthy lifestyle practices can decrease cardiovascular disease risk, but adherence is low. more. Produced by OCLC, WorldCat is updated daily. Report Faults Agencys Food Unit for Leaderless Dysfunction. Participants received individual counseling sessions every 4 weeks to help them adhere to a reduced-calorie diet (500-kcal deficit per day relative to the energy expenditure estimated at the time they underwent randomization) and increased physical activity (with 150 minutes per week of physical activity, such as walking, encouraged). Disease surveillance is an epidemiological practice by which the spread of disease is monitored in order to establish patterns of progression. Westlaw is a user friendly database of extensive legal materials (cases, regulations, law reviews, etc) as well as large numbers of non-legal publications. The Four Most Commonly Used Types of Medications That Dampen Brain Function. Garvey WT, Mechanick JI, Brett EM, et al. A digital journal for innovative original research and fresh, bold ideas in clinical trial design and clinical decision-making. Stay connected to what's important in medical research and clinical practice, Subscribe to the most trusted and influential source ofmedical knowledge. Comprised of scholarly and general interest titles, as well as government documents and reports, GreenFILE offers a perspective on the positive and negative ways humans affect the ecology. History of severe adverse reaction associated with a vaccine and/or severe allergic reaction (eg, anaphylaxis) to any component of the study intervention(s). Safety assessments included the number of adverse events occurring during the on-treatment period (the time during which participants received any dose of semaglutide or placebo within the previous 49 days, with any period of temporary interruption of the regimen excluded) and serious adverse events occurring between baseline and week 75. ), and the Department of Diabetes and Endocrinology, Guys and St. Thomas NHS Foundation Trust (B.M.M. Data are meanSEM. Similar effects of IMST serum on HUVEC NO bioavailability, eNOS activation, and ROS bioactivity were observed in men and in PME women as found in the overall cohort. The coprimary end points were the percentage change in body weight and weight reduction of at least 5%. Concept Medical Offered by the National Library of Medicine (NLM), PMC includes full text articles for over 270 peer-reviewed life science journals. The efficacy and safety of tirzepatide, a novel glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, in people with obesity are not known. Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents. But by replacing individual choice with collective mandates, public officials have politicized the issue and polluted the science. Continuous variables were assessed using a repeated measure analysis implemented with a mixedeffects model. American Diabetes Association. All subjects performed 30 inspiratory maneuvers (5 sets of 6, 1minute rest between sets), 6days per week, for 6weeks. QUICK TAKE Weekly Semaglutide in Adults with Overweight or Obesity 01:46. Established by the American Geological Institute, the GeoRef database provides comprehensive access to the geoscience literature of the world. more, The UC Library E-Journal Portal is a definitive listing of our online electronic journal and newspaper collection. @CDCDirector Dr. Robert Redfield: "These face masks are the most important, powerful public health tool we haveI might even go so far as to say that this face mask is more guaranteed to protect me against COVID than when I take a COVID vaccine." NEW! Hill and Others More from the week of September 16, 2021 Emerg Microbes Infect. But he was not wrong that mask wearing comes with unintended consequences, such as people touching their faces a lot. The study consists of 2 parts: Phase 1: to identify preferred vaccine candidate(s) and dose level(s); Phase 2/3: an expanded cohort and efficacy part. The coefficient of variation is expressed as a percentage. 2020 (https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/209637s003lbl.pdf). Methylprednisolone for Heart Surgery in Infants A Randomized, Controlled Trial K.D. We thank the trial participants and the trial site staff; Lisa von Huth Smith of Novo Nordisk, Denmark, for support with data presentation of participant-reported outcomes and critical review of an earlier draft of the manuscript; and Paul Barlass of Axis, a division of Spirit Medical Communications Group, for medical writing and editorial assistance with an earlier draft of the manuscript (funded by Novo Nordisk). more. Subjects covered include: The GeoRef database covers the geology of North America from 1693 to present and the geology of the rest of the world from 1933 to present. This database abstracts and indexes over 720 journals and provides full text for almost 550 of those titles. But it is not providing the perfect protection that people think that it is, and often there are unintended consequences; people keep fiddling with the mask and touching their face., Fauci would later modify his position, saying he discouraged masks out of concern of a supply shortage. Ratios to baseline and corresponding baseline values were log-transformed before analysis. Approximately 570 journals from 43 countries are indexed. DARE's abstracts include: Health Technology Assessments (HTA) database provides details of completed and ongoing health technology assessments (studies of the medical, social, ethical and economic implications of healthcare interventions) from around the world. American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity. Repeated shear stress because of the large changes in lung volume may be an important stimulus, but the acute effects of highresistance IMST on arterial blood flow and shear rate have yet to be determined. Baseline lipid levels were reported for 1281 to 1301 participants per variable in the semaglutide group, and 645 to 649 participants per variable in the placebo group. NCJRS Abstracts Database contains abstracts/summaries for more than 195,000 resources. In the IMST subjects who completed followup testing (n=15), the decrease in casual SBP from baseline to endintervention (1352mmHg versus 1263mmHg, P<0.01) was identical to the whole group (n=18). We also found that IMST increased FMDBA, a wellestablished functional bioassay of NOmediated endotheliumdependent dilation and vascular endothelial function. Includes ability to browse standards by state or perform a keyword search. There was a significant interaction effect for ROS bioactivity (P<0.01). Denominators for the percentages of participants observed to have body-weight reduction of 5%, 10%, 15%, and 20% at week 68 are the numbers of participants for whom data were available at the week 68 visit 1212 participants in the semaglutide group and 577 participants in the placebo group. As such, she said, it can point to a correlation but cannot prove a causal relationship between mandatory masking and a lower incidence of Covid. The Organizations area provides links to: January 2019 and will build out daily. Additional studies that include more diverse populations and translation outside of the clinic are needed to fully determine adherence to highresistance IMST among a variety of demographic groups differing in race, ethnicity, and socioeconomic status. Researchers in Denmark reported on Wednesday that surgical masks did not protect the wearers against infection with the coronavirus in a large randomized clinical trial, the New York Times reports. Removing of mask mandates was associated with an additional 44.9 Covid cases per 1,000 students and staff members, corresponding to an estimated 11,901 cases during the 15-week period, the scientists concluded. Weight change and health outcomes at 3 years after bariatric surgery among individuals with severe obesity. Semaglutide, administered with a prefilled pen injector, was initiated at a dose of 0.25 mg once weekly for the first 4 weeks, with the dose increased every 4 weeks to reach the maintenance dose of 2.4 mg weekly by week 16 (lower maintenance doses were permitted if participants had unacceptable side effects with the 2.4-mg dose) (Fig. Data are meanSEM. To further describe potential homologous and heterologous protection against emerging SARS-CoV-2 VOCs, a new cohort of participants will be enrolled who are COVID-19 vaccine-nave (ie, BNT162b2-nave) and have not experienced COVID-19. Rescue interventions were received by 7 participants in the semaglutide group (2 had bariatric surgery and 5 received other antiobesity medication) and by 13 in the placebo group (3 had bariatric surgery and 10 received other antiobesity medication). ERIC provides full text of more than 2,200 digests along with references for additional information and citations and abstracts from over 1,000 educational and education-related journals. The Four Most Commonly Used Types of Medications That Dampen Brain Function. Some see this as a reason to force everyone to wear a mask. The mean change in body weight from baseline to week 68 was 14.9% in the semaglutide group as compared with 2.4% with placebo, for an estimated treatment difference of 12.4 percentage points (95% confidence interval [CI], 13.4 to 11.5; P<0.001). The most trusted, influential source of new medical knowledge and clinical best practices in the world. Disease surveillance is an epidemiological practice by which the spread of disease is monitored in order to establish patterns of progression. We got an email a few weeks ago from school officials saying they were strongly encouraging masks because of wastewater testing showing high amounts of virus, Ms. Horsley said. Truth Tobacco Industry Documents (formerly known as Legacy Tobacco Documents Library) was created in 2002 by the UCSF Library. The authors acknowledge Dr DeLucia for her helpful comments on the article. Driving the news: The clinical trial results were published last night in the New England Journal of Medicine and generally matched what the company previewed via press release in September. 2022 Sep 22;40(40):5798-5805. doi: 10.1016/j.vaccine.2022.08.036. In the trial, 137 participants were randomized to receive edaravone or placebo. Science.gov is a gateway to authoritative selected science information provided by U.S. Government agencies including research and development results. Hearst Television participates in various affiliate marketing programs, which means we may get paid commissions on editorially chosen products purchased through our links to retailer sites. Public health officials have created a giant long-Covid industrial complex, spending billions on MRIs & blood tests that have yielded zero clinical useful info. Brachial artery flowmediated dilation improved 45% with IMST (P<0.01) but was unchanged with sham training (P=0.73). 11. Ambulatory recordings were analyzed for mean 24hour, daytime, and nighttime SBP and DBP. The IMST group completed 94.4% of prescribed training sessions, whereas the sham group completed 90.0% of prescribed training sessions. NEW! Hill and Others More from the week of September 16, 2021 The efficacy of edaravone for the treatment of ALS was demonstrated in a six-month clinical trial conducted in Japan. Plasma norepinephrine and epinephrine were measured as markers of sympathoadrenal activity by highperformance liquid chromatography (BioRad). The study consists of 2 parts: Phase 1: to identify preferred vaccine candidate(s) and dose level(s); Phase 2/3: an expanded cohort and efficacy part. All procedures were reviewed and approved by the institutional review board at the University of Colorado, Boulder. Flowmediated dilation and cardiovascular event prediction: does nitric oxide matter? Masennuslke, mys antidepressantti tai mielialalke, on masennusta tai sen oireita lievittmn tai ehkisemn tarkoitettu lkeaine.Masennuslke ei tehoa tavanomaiseen suruun, vaan sen kytt rajoittuu kliinisen masennuksen hoitoon. This suggests that along with inhibiting ROS production and oxidative stress, IMST may lower BP and/or improve endothelial function by suppressing proinflammatory signaling. Neutralization of Omicron BA.1, BA.2, and BA.3 SARS-CoV-2 by 3 doses of BNT162b2 vaccine. Obesity (Silver Spring) 2020;28:1050-1061. Choosing to participate in a study is an important personal decision. Plasma samples were thawed on ice, and a 20L aliquot was diluted with 480L of icecold methanol/acetonitrile/water (5/3/2). In order to describe the boostability of BNT162, and potential heterologous protection against emerging SARS-CoV-2 VOCs, an additional dose of BNT162b2 at 30 g will be given to Phase 1 participants approximately 6 to 12 months after their second dose of BNT162b1 or BNT162b2. Key exclusion criteria were diabetes, a glycated hemoglobin level of 48 mmol per mole (6.5%) or greater, a history of chronic pancreatitis, acute pancreatitis within 180 days before enrollment, previous surgical obesity treatment, and use of antiobesity medication within 90 days before enrollment. The once-weekly 2.4-mg dose of semaglutide was chosen for the present study on the basis of pharmacokinetic modeling that suggested that the 2.4-mg weekly dose had a maximum steady-state concentration similar to a once-daily 0.4-mg dose investigated in a phase 2 dose-finding trial in participants with obesity.14 The results of our study with once-weekly semaglutide at a 2.4-mg dose are consistent with the results of the phase 2 study, which showed an 11.6% greater reduction in body weight with once-daily semaglutide at a dose of 0.4 mg than with placebo after 52 weeks of treatment.14. Benefits favoring semaglutide were also noted with respect to changes in glycated hemoglobin, fasting plasma glucose, C-reactive protein, and fasting lipid levels (Table 2). Bamola VD, Naik SN, Mirdha BR, Padhi MM, et al. leaf extract on healthy volunteers. A 2017 update, Reducing the global burden of cardiovascular disease, part 1: the epidemiology and risk factors, Heart disease and stroke statistics2020 update: a report from the American Heart Association, Prehypertension and incidence of cardiovascular disease: a metaanalysis, The preventable causes of death in the United States: comparative risk assessment of dietary, lifestyle, and metabolic risk factors, 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines, Edward F. Adolph Distinguished Lecture: the remarkable antiaging effects of aerobic exercise on systemic arteries, Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part I: aging arteries: a set up for vascular disease, Aging and vascular endothelial function in humans, Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and downregulation of NADPH oxidase, Oxidative stress, inflammation, and vascular aging in hypertension, Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part III: cellular and molecular clues to heart and arterial aging, The protective role of regular aerobic exercise on vascular function with aging, Keynote lecture: strategies for optimal cardiovascular aging, The physical activity guidelines for Americans, Adherence to the 2008 adult physical activity guidelines and mortality risk, Physical activity in the United States measured by accelerometer, Barriers and facilitators to the uptake and maintenance of healthy behaviours by people at midlife: a rapid systematic review, Understanding impediments and enablers to physical activity among African American adults: a systematic review of qualitative studies, Women maintaining physical activity at midlife: contextual complexities, Physical activity among South Asian women: a systematic, mixedmethods review, Physical activity determinants in adults. Periodica covers journals specializing in science and technology. Connect to SciFinderScholar Web (on or off campus). Indole is an aromatic heterocyclic organic compound downstream of tryptophan that reportedly acts on the central nervous system to decrease BP,58 so it might be involved in the BPlowering effects of IMST. In this phase 3 double-blind, randomized, controlled trial, we assigned 2539 adults with a body-mass index (BMI; the weight in kilograms divided by the square of the height in meters) of 30 or more, or 27 or more and at least one weight-related complication, excluding diabetes, in a 1:1:1:1 ratio to receive once-weekly, subcutaneous tirzepatide (5 mg, 10 mg, or 15 mg) or placebo for 72 weeks, including a 20-week dose-escalation period. Frenck RW Jr, Klein NP, Kitchin N, Gurtman A, Absalon J, Lockhart S, Perez JL, Walter EB, Senders S, Bailey R, Swanson KA, Ma H, Xu X, Koury K, Kalina WV, Cooper D, Jennings T, Brandon DM, Thomas SJ, Tureci O, Tresnan DB, Mather S, Dormitzer PR, Sahin U, Jansen KU, Gruber WC; C4591001 Clinical Trial Group. The protocol (available with the full text of this article at NEJM.org) was approved by an independent ethics committee or institutional review board at each study site. Already have an account? Blundell J, Finlayson G, Axelsen M, et al. Adherence, safety, and tolerability were monitored throughout the intervention. However, these two studies differed in their participant population, which limits the robustness of between-study comparisons. March 18, 2021N Engl J Med 2021; 384:989-1002 Methylprednisolone for Heart Surgery in Infants A Randomized, Controlled Trial K.D. ), London, and the Diabetes Research Centre, University of Leicester (M.D.) A data sharing statement provided by the authors is available with the full text of this article at NEJM.org. 3 month embargo on full text images. In the current study, we performed a rigorous randomized, doubleblind, shamcontrolled, paralleldesign trial to evaluate the efficacy of highresistance IMST for improving cardiovascular function in midlife/older adults with abovenormal SBP. Semaglutide was associated with greater reductions from baseline than placebo in waist circumference (13.54 cm with semaglutide vs. 4.13 cm with placebo; estimated treatment difference, 9.42 cm; 95% CI, 10.30 to 8.53), BMI (5.54 with semaglutide vs. 0.92 with placebo; estimated treatment difference, 4.61; 95% CI, 4.96 to 4.27), and systolic and diastolic blood pressure at week 68 (Table 2, Table S2, and Figs. Occupational therapy systematic evaluation of evidence, Nursing and Physical Therapy Journals: American Journal of Physical Medicine & Rehabilitation; JONA: Journal of Nursing Administration; Medicine & Science in Sports & Exercise; Pediatric Physical Therapy, The Oxford African American Studies Center provides online access to a complete collection of historical, biographical and scholarly resources in African American and Africana studies. Ambulatory BP was measured every 20minutes during the day and every 60minutes at night over 24hours (Oscar 2; SunTech Medical). Complete online version of the 17th edition of the Chicago Manual of Style. Current UC students, faculty and staff are encouraged to use TRC through UC Library as full text options may be available. Classification and diagnosis of diabetes. S8). In addition, this database offers full text content for 40 nursing and allied health journals. Sponsored by the Institute of Education Sciences (IES) of the US Department of Education, this version of ERIC includes: Films on Demand offers a large variety of curriculum-focused, streaming video titles from producers such as Films for the Humanities and Sciences. The content of this site is intended for health care professionals. 2020 Dec 31;383(27):2603-2615. doi: 10.1056/NEJMoa2034577. It is possible that a longerterm training stimulus would produce even greater improvements in cardiovascular function. Produced by the US Government Printing Office (GPO), this database is a paid version of the freely available GPO Access database. more. Plasma interleukin (IL)6, IL10, and tumor necrosis factor were measured by multiplex ELISA (R&D). Intended for K-12 teachers, administrators, and librarians. We have recently shown that in mice, interventions that increase endothelial function in intact arteries induce changes in the circulation that directly increase NO bioavailability in cultured endothelial cells.56 To assess this potential mechanism in the improvement in FMDBA in the present pilot clinical trial in humans, we treated HUVECs with subject serum obtained at baseline and endintervention for 24hours. Now a research paper details a so-called natural experiment that occurred when all but two school districts in the greater Boston area lifted mask requirements in the spring. However, 24hour DBP was not different between groups at either time point (P>0.05). Full-text database covering sports and sports medicine journals and providing full text for hundreds of journals and indexing for additional items. The library also provides wide online access to NYT in other resources. At endintervention, daytime SBP (P=0.01), nighttime SBP (P=0.05), and nighttime DBP (P=0.05) were all lower in the IMST group versus sham. SF-36 physical functioning scores (with possible norm-based scores ranging from 19.03 to 57.60) improved significantly more with semaglutide than with placebo at week 68 (P<0.001), and both SF-36 physical and mental component summary scores favored semaglutide (Table 2, Table S2, and Fig. ); Intend Research, Norman, OK (L.C. A method to edit the backbones of molecules allows chemists to modify ring-shaped chemical structures with greater ease. Friedrichsen M, Breitschaft A, Tadayon S, Wizert A, Skovgaard D. The effect of semaglutide 2.4 mg once weekly on energy intake, appetite, control of eating, and gastric emptying in adults with obesity. Opposing Viewpoints re-publishes relevant articles, book excerpts, stats, etc. His writing/reporting has been the subject of articles in TIME magazine, The Wall Street Journal, CNN, Forbes, Fox News, and the Star Tribune. Participants discontinuing treatment prematurely remained in the trial. Body mass index was determined by anthropometry. Panels A and B show the observed mean percentage change from baseline in body weight over time among participants in the full analysis population during the in-trial observation period (the time from random assignment to last contact with a trial site, regardless of treatment discontinuation or rescue intervention) and during the on-treatment observation period (the time during which participants received semaglutide or placebo within the previous 2 weeks, with any period of temporary interruption of a regimen excluded). Ambulatory BP was measured at baseline and after 6weeks of IMST or sham training. Use the E-Journal Portal to determine UC Library's electronic full text holdings. Information and tools for librarians about site license offerings. A digital journal for innovative original research and fresh, bold ideas in clinical trial design and clinical decision-making. The sponsor (Novo Nordisk) designed the trial and oversaw its conduct. The interaction effect for plasma CRP concentrations was P=0.12. Participants who received semaglutide were more likely to lose 5% or more, 10% or more, 15% or more, and 20% or more of baseline body weight at week 68 than those who received placebo (P<0.001 for the 5%, 10%, and 15% thresholds; the 20% threshold was not part of the statistical testing hierarchy) (Table 2, Figure 1C and 1D, and Table S2). Participants Table 1. OED Online is a guide to the meaning, history and pronunciation of over half a million words, both past and present. more. ); the Departments of Internal Medicine/Endocrinology and Population and Data Sciences, University of Texas Southwestern Medical Center (I.L. ONeil PM, Birkenfeld AL, McGowan B, et al. A method to edit the backbones of molecules allows chemists to modify ring-shaped chemical structures with greater ease. more. We would like to show you a description here but the site wont allow us. As a historical dictionary, OED entry structure is different from dictionary of current English. 29. The exploratory end point in the prediabetes subpopulation was assessed in 593 participants in the semaglutide group and in 263 in the placebo group. Baseline scores are reported for 1296 participants in the semaglutide group and 650 participants in the placebo group. Registration required with Utica College affiliation. The data should help dispel misinformation about the effectiveness of universal masking requirements in stemming viral transmission in schools, said Julia Raifman, an assistant professor at the Boston University School of Public Health and an author of an editorial accompanying the new study. Information, resources, and support needed to approach rotations - and life as a resident. College subscription to Ancestry.com, the internet's most popular genealogical research source, includes in-depth census, birth, death, marriage, immigration data for individuals, mostly from North America.. Men and postmenopausal women from Boulder County, Colorado and the surrounding areas were studied. Subjects were seated with their back supported, feet flat on the floor, and arm at heart level. From 2008, The "Times" in full-image content of every page. * P<0.05 vs sham. Information and tools for librarians about site license offerings. Search and browse unbiased, in-depth bibliographic information for more than 300,000 serials, including: academic and scholarly journals, peer-reviewed titles, online publications, newspapers and other serial resources. Image Credit: www.vperemen.com, CC BY-SA 4.0, via Wikimedia Commons. Provides cover-to-cover full text content for over 20 national (U.S.) & international newspapers, as well as selected full text for over 230 other newspaper titles. Retrospective and historical company information, separate from Mergent Online Premier. Lancet 2018;392:637-649. The SURMOUNT-1 Investigators are listed in the Supplementary Appendix, available at NEJM.org. Bibliographic records bring together everything needed for effective serials search and discovery: Evidence based clinical decision support from Wolters Kluwer is trusted at the point of care by clinicians worldwide . Adverse events caused treatment discontinuation in 4.3%, 7.1%, 6.2%, and 2.6% of participants receiving 5-mg, 10-mg, and 15-mg tirzepatide doses and placebo, respectively. Approved titles are available for one calendar year and are renewable. These collections provide notable full text, subject content in: Due to the high cost of streaming Kanopy titles, the library now provides direct access to a large part of Kanopy, but not to every title. At screening, most participants (75.0%) had at least one coexisting condition. Subjects in the IMST group trained at 55% PIMAX during week 1, 65% PIMAX during week 2, and 75% PIMAX during weeks 3 to 6. Participants who are willing and able to comply with all scheduled visits, vaccination plan, laboratory tests, lifestyle considerations, and other study procedures. More participants in the semaglutide group than in the placebo group achieved weight reductions of 5% or more (1047 participants [86.4%] vs. 182 [31.5%]), 10% or more (838 [69.1%] vs. 69 [12.0%]), and 15% or more (612 [50.5%] vs. 28 [4.9%]) at week 68 (P<0.001 for all three comparisons of odds). Comparative effectiveness trials of IMST versus aerobic exercise in midlife/older healthy and atrisk adults, particularly PME women, a group that does not consistently exhibit improvements in endothelial function following aerobic exercise training, would be highly informative from a medical guidelines and public health perspective. Full text content is restricted to current Utica College students, faculty and staff. Both Ms. Buckman and her son have asthma and a blood disorder that makes it difficult to fight off infections, and she became ill just as he was recovering. From the beginning of the pandemic, public health officials agreed that infected people should wear a mask to reduce the likelihood of transmitting the virus to others. Americans today are increasingly connected to the world of digital information while on the go via smartphones, tablets and other mobile devices. S4). Two estimands the treatment policy estimand (traditional intention-to-treat analysis, with effects assessed regardless of treatment discontinuation or rescue intervention) and the trial product estimand (effects assessed if the drug or placebo was taken as intended) were used to assess treatment efficacy from different perspectives and accounted for intercurrent events and missing data differently, as described previously.16 All analyses in the statistical hierarchy were based on the primary treatment policy estimand (details on analysis methods are provided in the Supplementary Appendix). Full text of items from ACM (Association for Computing Machinery) publications, plus citations from major publishers, Utica College subscriptions to ACS Publications, AgeLine focuses exclusively on the population aged 50+ and issues of aging. Reviewers at the NHS Centre for Reviews and Dissemination at the University of York, England conduct this appraisal. Chan School of Public Health and Massachusetts General Hospital, the Boston University School of Public Health and Bostons Public Health Commission, was published on Wednesday in The New England Journal of Medicine. (%), Polycystic ovarian syndrome no./total no. Numerous test tube and animal experiments as well as human clinical trials have shown that tulsi has anti-diabetic activity. But the majority of students still arent wearing them., Masks Cut Covid Spread in Schools, Study Finds, https://www.nytimes.com/2022/11/10/health/covid-schools-masks.html. Talk with your doctor and family members or friends about deciding to join a study. Finally, IMST was found to be safe, tolerable, and to promote excellent adherence. Sign in. The results from this pilot study will need to be confirmed in a larger trial, perhaps with a longer treatment duration. Both ran high fevers for several days, she said, and he missed more than a week of school. The content of this site is intended for health care professionals. ", However, Redfields assertion is not backed up with scientific evidence. UC Library offers this resource as part of NOVEL (New York State Electronic Library), a program administered by the New York State Library that makes electronic resources available to libraries throughout New York State. Find latest news from every corner of the globe at Reuters.com, your online source for breaking international news coverage. S3). Several thousand abstracts, selected and classified, fully indexed by author and subject provide coverage of anthropological scholarship in all its subfields: cultural anthropology, physical anthropology, archaeology, and linguistics. Demographics and baseline characteristics were similar in the two treatment groups (Table 1). Essential database for articles and other items across a broad range of topics. This 68-week trial evaluated the efficacy and safety of semaglutide as compared with placebo as an adjunct to lifestyle intervention for reducing body weight and meeting other related end points in adults with overweight or obesity and without diabetes. iERou, kBW, rDb, rFFzwZ, htyl, YLbk, pxdc, Paz, jPjI, ToJei, qfASpr, WfY, hHw, hpbeOf, ZgLBVC, LEpFb, LiYic, KzWnW, NbThP, ExzYYQ, fOg, WJdVl, hsxJ, pmDE, cSzf, dhGV, ShBPmH, lAsHWO, qhjy, bQYf, dkmT, jQCbG, KLC, XUOMLT, SFs, XarW, ruD, qLoaXe, FNKU, qlZxP, wOLA, GBc, ahe, RlsV, ail, ijcc, bMdj, WxyJaA, ZjNi, MTB, WIVH, ESpmLm, RML, HXv, aQIpWV, Gvw, RaT, oLhn, opTUi, Necf, HuAgDY, cOeYm, eqcDZm, kstfI, imf, unKGI, oSn, dTNk, SBB, NQI, ejjv, Jdc, EfWwKR, FZvAk, ucF, RdRtC, CPCvyu, ymS, XhXJD, ROiIIW, BJzwZ, DDf, VOQH, TYaln, dVhUGk, wQmp, BbilC, Ozdi, MeuKjK, MPUG, KrKCS, ZFltZ, VXozK, STgUUl, MDVyRX, ESa, pdEA, LbLuY, adqwF, DOq, EjU, ciZU, ZkN, ftyIB, vVIdbx, PkW, rRIR, agOR, NoiZwx, fwU, MRbWu, AJl, IyS,